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Adorable Brand New Skyline Park Model Tiny Home in Texas for sale - Duration: 2:29.
Adorable Brand New Skyline Park Model Tiny Home in Texas for sale
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Sofia The First Lovely Moments Best Cartoon For Kids & Children - Part 981 - Red Elephant - Duration: 14:36.
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The buttercups
Our troops newest members peg and Meg I'm Meg she's
Sorry about that. It's okay. Our brother gets us mixed up all the time
Me neither Thank You Sofia
I'm the most excited ever
You explore the great outdoors and learn new things and for every new activity you do you get a badge
Would you put on your vest I got this one and tomorrow you'll all get a chance to earn
Plenty of badges because we're going on a nature hike through the pepper tree forest
Don't worry you'll earn a pledge tomorrow on time to go girls
I don't know that the forest is a proper place for a princess Oh, she'll be fine
You know Sofia was a buttercup before she was a groundhog Scout as a boy exploring the great outdoors gave me skills
I used to this very day. I think princess Sofia would learn a lot by going. That's it
Not a one your majesty dad. I don't need baileywick. I'll be fine on my own
You'll be even more fine with baileywick. I just want to make sure that - what - what - - oh
Dear no worries. I have a sewing kit in my back princess Sofia of enchancia
Alrighty then let's
Move out buttercups and you too groundhog
Let's put the great and hold up buttercups time for water break, finally
Allow me princess
It's your throne away from home. What do we have to do? You have to build a birdhouse out of twigs and bark
Already then go to it buttercups
Biggest birdhouse, I'm going to make the best birdhouse
Each Buttercup must do the project by herself. Yes mrs
Hanshaw I know but I only helped a little Sofia found the tree bark
Mm-hmm, just like you that's right. I
Know how you feel? We didn't get a badge either. You'll get one. Just keep trying
That's right. Well, it's time you made some room. So your Buttercup can bloom we can't do it all for them now
They'll never learn back on the trail buttercups
But it's so slippery
Is it now hmm
Here we go buttercups who can tell me what badge this is. Oh
I hate to interrupt mr. Squirrel, but I could really use that log. Oh why certainly?
Just a moment while I finish up lunch. Yep
nice work girls
Hmm I'm just holding them for the princess
And here's your badge Ruby
Thanks mom
Jade you've earned your last badge and that me
Allow me
I'm going to talk to him you gave her a groundhog word. I did didn't I?
Okay, the next project by yourself no matter what
buttercups, it's time to find out how well you know your
wildflowers everyone must pick a bouquet of daisies and daffodils but because
What if she touches the meddlesome Myrtle
There I've got enough babies, oh you did it Ruby you got your final badge I'm so proud of my girl
Look there's the red rash. Oh
Gee but fine
It'll be okay baileywick
Are you sure he's going to be all right, I think so Sophia the trail is so twisty and steep
It'll be hard for baileywick to climb down. Mm-hmm. Maybe there's another way to get down the mountain
Don't you think we can do it all we need to do is work together?
We'll gather big pieces of wood like we did for the campfire and tie them together like we did with the birdhouses
Let's do more looks like Sofia's doing just fine on our own baileywick
You are prepared
Well, how does he look doctor
Oh, that's a nasty case of meddlesome Myrtle, but he'll be all right Your Majesty would have reminded you of well your itself
Are you okay baileywick? I'm going to be fine Sofia you do to heal Sofia me. Please step forward
Sofia when you found a way to get baileywick back home you were
Congratulations all of you. That'll be you someday
Sofia I'm so proud of you edge the being prepared badge
I'm honored. Mrs. Hanshaw, but I'm afraid I can't put it on Oh
You
The mayor of the mist
Minimus can you do it going down? That's guy
And I have miss you my princess
Huh? That's a long hug. Oh, you must be sky. I
Was my good man, but since I last saw her I have become quite accomplished
Christa hello. This little beauty can get you out of a lot of jams
Tell it where you want to go and a boom a magical arrow guides you there watch
But mine doesn't have a bowstring
Of course, there's no bowstring princess since you're non-magical and wingless
You're gonna need a flying steed for protector assignments like this and I have humbly volunteered for the job my princess. Oh
That's some sweet sky to do the thing. You want to be a protector. See sure. Why not Wow
I mean it's not often a protector in training gets to offers like this move it
Christa could I talk to you in private for a moment
Okay. Sure. Excuse me, guys
You want me to choose between an O
It's more of a guideline good because I really feel like I should take both you can't do that
Why not because even a princess can't fly two horses that alene great what think of it as a tryout
Whichever one of you does better on this assignment will get the job permanently. I think it's pretty obvious who that's gonna be
But can you see her in the mist guys, please?
Okay
You gotta get the mayor of the miss to give you a single strand from her Mane
That's going to be the bowstring for my which way bow
But you do what you know is right no matter what anyone else is. Oh, yes, that is definitely my princess
There's nothing to worry about
Except number two. Yes, but sky hasn't had a chance yet
Listen princess a protector doesn't mess around when they're in a hurry saying well, maybe I'll do this
Was there something you wanted so
beautiful
Christa said she's skittish guys. So let's be quiet. You got us fear
And if you decide to fly the rest of the way, I'm your guy. That's okay a quiet remember?
She's right. You stand thither I'll stand yon thither and yon
I got it. I got it. I'm yep
Not yet Christa, we found her but we may have scared her off
Sorry about that agreed and we have to find the Merrigan
Is that her yonder in the sky? It's just a cloud methinks tis. She
See it is her who shall you ride my princess I'll go with minimus because he's faster
Perhaps I might be of assistance
Fantastic we can use your light to fight turn chef Cory. Stay close minimus
It's not the mayor knave it was a high cliff hawk. Are you sure that's not the mayor shall I follow him?
Or the mayor of the mist. Oh, I don't know
Come on, Sofia. Think like a protector
Okay
You're running out of time
So what happened we uh, we we lost the mayor
We followed a hawk instead
We didn't follow a hawk Sofia
But this is your job if you want to get your bowstring and be a protector, you gotta make a choice
Right now see you back at the stables if you ever happened by that way again
Now you need to get back to work princess, there's no time for that you're running out of daylight
Come my princess. I will help you complete the task
Okay
My name is no you may not know only those who are true of heart
Are a worthy of a magical bowstring?
So what shall we do what we should have done before we're going to get minimus back but what about the which way Poe
Going in circles story of my life
It was wrong of me to choose between you two you both are important to me
I don't blame you for choosing Scott. You didn't Sophia you're my friend
I should never have told you to leave you are right tis
I who should go minimus is your brave and loyal friend. If you were true to yourself about being true to my heart
Minimus while you were gone the mayor refused to give me a strand of her mane what she thinks you're not true of heart
Well, maybe she'd give you a strand of her mane now
Do you think we can find her but the days not over yet? Huh? We said that at the same time
It's me again Sofia
When I saw you earlier you were right. I wasn't true of heart. I picked a new friend over an old one
Binky may you use it wisely?
I couldn't find her with four hooves and a map weight the weights weibo. Why didn't I think of that?
Strings upload
Clip back looks like someone got her bowstring and look who's back
I couldn't have done it without them full event. So you followed your heart no matter what anyone else Skye
I am honoured but would you not be better served by the noble minimus?
No one could serve me better in the mystic Isles the new sky, but that sure why not
We make a great team
Yeah, that's really sweet but can you use that which way bow to take us home
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MUNI TUNNEL MAKEOVER: Workers begin a makeover for MUNI's Twin Peaks tunnel - Duration: 2:32.
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Gene therapy for blood disorder may be effective - Duration: 3:40.
Gene therapy for blood disorder may be effective
Gene therapy for patients with a severe form of the blood disorder beta-thalassemia could be safe and effective as well as end the need for transfusions, results from the clinical trials show.
New York: Gene therapy for patients with a severe form of the blood disorder beta-thalassemia could be safe and effective as well as end the need for transfusions, results from the clinical trials show.
Beta-thalassemia is a genetic disorder that impairs the bodys ability to produce a key component of hemoglobin -- a critical protein in red blood cells that carries oxygen to organs and tissue. People with the most severe forms of beta-thalassemia require monthly blood transfusions, right from their toddler age, to replenish their red blood cell supplies along with iron chelation to remove extra iron from the body.
Frequent transfusions, however, can cause serious complications due to iron toxicity and viral infections.
The results, published in New England Journal of Medicine, showed that a one-time treatment with the gene therapy known as LentiGlobin BB305 vector reduced or eliminated the need for blood transfusions in 22 patients with severe beta-thalassemia.
We saw remarkable outcomes using LentiGlobin gene therapy, with most patients no longer needing monthly transfusions, said lead author Alexis Thompson, from Ann & Robert H.
Lurie Childrens Hospital of Chicago. These study results exceeded our expectations with clinical benefit for nearly all patients and suggest that gene therapy may be an effective treatment for thalassemia in the future, Thompson added. Of the 22 patients aged between 12 and 35 years, 15 patients achieved transfusion-free status, while others needed transfusions less often.
All the patient underwent chemotherapy, after which they were infused with their own stem cells that were treated in the lab with a modified virus to replace the gene that is defective in thalassemia.
Patients typically reached peak production of hemoglobin in 9-12 months after infusion. While these gene therapy trials were the largest for thalassemia to date, we need to evaluate effectiveness in a much larger population, Thompson said, adding that they are now enrolling patients as young as five-years-old on a Phase 3 trial.
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Leeds United: Paul Heckingbottom fighting for job after just three months in charge - Duration: 2:43.
Leeds United: Paul Heckingbottom fighting for job after just three months in charge
Heckingbottom's future is in doubt following crunch talks with Andrea Radrizzani last week which left Leeds Italian owner considering his manager's future.
Radrizzani and his board are not sure Heckingbottom is the right man to lead a promotion push next season after the former Barnsley chief, 40, failed to make the expected impact as Thomas Christiansen's replacement.
Christiansen got the bullet in February after just eight months in charge because he couldn't maintain United's assault on the play-offs.
But the Dane won 15 of his 35 games at the helm and the fallen Yorkshire giants were still in touch with the Championship's top six when he was axed.
But he won only four and lost eight of his 16 games before the campaign ended with Leeds in 13th place.
Massimo Cellino, Radrizzani's sack-happy predecessor, worked his way through six managers in his crazy three-year reign at Elland Road, and his successor is anxious not to be tarred with the same brush.
But Radrizzani is totally committed to returning Leeds to the Premier League and won't hesitate to appoint his third boss in 12 months if he believes a change of manager gives them the best chance of promotion next season.
Former Chelsea and Premier League winning Leicester chief Claudio Ranieri has already been touted as a possible replacement, while ex-Swansea manager Michael Laudrup is being linked after leaving Saudi outfit Al Rayyan.
Leeds are also keeping an eye on Steve Bruce's situation following Aston Villa's defeat by Fulham in last Saturday's Championship play-off final.
Villa boss Bruce has already won four promotions to the top flight as a manager - two at Hull and two more with Birmingham.
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wild animals finger family song for kids | nursery rhymes,white vs colore wilad animals,learn colors - Duration: 3:41.
wild animals finger family song for kids
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