Supplements For Brain Health.
Most people believe a progressive decline in overall brain function is a natural process
of aging.
This degenerative process causes us to lose our short-term memory and abstract reasoning
ability.
It also may make concentration or learning new information difficult.
Many neurological diseases are also directly related to aging such as dementia, Alzheimer's,
and Parkinson's.
Many published studies have shown that the decline of brain function can be delayed,
or even reversed, by proper diet and/or supplementation.
This report is a review of the existing research done on the ingredients in Melaleucas Unforgettables
dietary supplement.
-Omega-3s in Fish Oil Cold water fish is high on the list of brain
foods because EPA and DHA, the omega-3 fatty acids found in cold water fish, have been
linked to enhanced memory and brain function.
The fish chosen by Melaleuca for the supplement Unforgettables are anchovy, mackerel, and
sardine.
These fish are small and live only a short time; not long enough to accumulate a buildup
of harmful mercury.
The fish are also pre-screened for mercury content before processing.
In the United States and Canada, omega-3 intake through diet alone is very low because it
is usually limited to canola oil, corn oil, and other cooking oils, as well as walnuts
and flaxseed oil.
These plant-based sources give us a form of omega-3 which then needs to be converted into
DHA by the body.
In women, the conversion rate to DHA is about 7%, and in men, it is less than 1%.
Needless to say, these plant-based sources of omega-3 are not the optimal way to feed
our brains with plenty of DHA, which is what is needed for best brain, eye, and heart functioning.
Since cold-water fish oil is already rich in DHA, adding it to the diet as a supplement
is the best way to provide your body with DHA.
Scientists working on a nine-year study completed in 2006 found that patients with dementia
have less DHA in their brains than patients of the same age without dementia.
There is a 47% reduction in risk for developing dementia when DHA levels in the brain are
high.
Free radicals do more damage in the aged brain when there is a deficiency of DHA because
DHA protects the brain from oxidative stress.
Studies are finding that supplementation with fish-based DHA, and another component of fish
oil known as EPA, can delay and lessen the impact of age-associated diseases like Parkinson's
and Alzheimer's.
Vitamin E and Blueberry Extract.
Vitamin E and blueberry extract act as antioxidants in Melaleucas Unforgettable.
The two of these are together in a single supplement because the synergy between them
increases their benefits.
Many studies have indicated that combinations of antioxidant vitamins, carotenoids and flavonoids
are believed to be more effective than supplementation with any of these nutrients alone.
Vitamin E is purported to be a very important ingredient for optimal brain health.
It could possibly slow the progression of Alzheimer's disease because it relieves oxidative
stress to brain cells.
The brain is rich in lipids (fatty compounds) which are susceptible to oxidative damage
from free radicals.
Oxidative stress can really damage memory function, and brain cells in general.
When the damage has been done, older adults start showing symptoms of age-associated memory
impairment.
In the brain, antioxidant molecules like those in vitamin E and blueberries wage war against
molecules known as free radicals, which can harm brain cells and brain function.
Vitamin E has actually been shown to block the death of neurons in the brain.
Essentially, a good vitamin E supplement can prevent or slow the rate of cognitive decline
as the brain ages.
Blueberries can alleviate inflammation in the brain and spinal cord, according to a
study done by Thomas Kuhn, Ph.D., of the University of Alaska.
Two of the most damaging players in brain aging are inflammation and oxidative stress.
We learned that vitamin E helps to alleviate the oxidative stress and now we find that
blueberries can help to lessen the inflammation of the spinal cord and brain tissue.
Blueberry can also strengthen the communication between neural cells and can actually REVERSE
damage done to the circuitry in the brain.
The neural circuitry in the brain tends to resemble a tree or leaf, with branches and
sub-branches feeding off the main stem.
In brains of memory-impaired rats, some of the branches have withered and become disconnected.
Studies were done on older memory-impaired rats that were fed a diet supplemented with
blueberries found that blueberry could return brain structure back to normal, as well as
prevent the breakdown of neuronal communication.
This made headlines for many health news outlets in November 2007
. Gingko Biloba is featured in all of Melaleucas ProVex products for cardiovascular health
because its properties include the improvement of blood flow and the ability to block the
effects of blood clotting.
It is added as an ingredient in Unforgettable for these reasons and because of another property,
it possesses the protection against oxidative cell damage from free radicals.
A recent six-month study on the effects of Gingko Biloba in the diet of ten patients,
with no dementia but mild memory loss, found that after supplementing with at least 120
mg twice daily, a verbal recall was improved.
PET scans showed better brain function in brain memory centers.
A French study found that long-term supplementation of Ginko Biloba enables cognitive performance
to be maintained for longer, and indicates that the development of Alzheimer's disease
can be prevented or at least delayed.
In a meta-review of previously published studies on Gingko Biloba related to memory function,
a small but significant effect to short-term recall was found when patients were treated
with 120 mg to 240 mg over three to six months.
Phosphatidylserine Phosphatidylserine (PS) is a phospholipid
normally found in nearly every cell in your body.
A phospholipid is a type of lipid.
Lipids add to cell structure and are a source of fuel.
In the brain, PS operates in part as a communication facilitator between nerve cells.
Most Phosphatidylserine research has been conducted with PS derived from the brain tissue
of cows and shows a substantial health benefit in age-related cognitive decline, but because
of concerns about the possibility of humans contracting infectious diseases such as "mad
cow" disease, this form is not available in the US.
More recent data suggests that the complexation of standardized Ginkgo Biloba extract (GBE)
with soy-derived phospholipids, the form used in Melaleuca's Unforgettables, enhances
the bio-availability of GBE's active components.
Results of a recent study utilizing Ginkgo Biloba extract with soy-derived phospholipids
showed that "administration of GBE complexed with Phosphatidylserine resulted both in improved
secondary memory performance and significantly increased the speed of memory task performance
across all of the post-dose testing sessions."
It appears from this study that Phosphatidylserine acts synergistically to enhance the cognitive
effects associated with a low dose of GBE.
Further research is required to identify whether this effect is due to the complexation of
the extracts, their mere combination, or the separate psychopharmacological actions of
the two extracts.
Conclusion The ingredients in Unforgettables are a well-chosen
blend of brain health ingredients whose positive synergistic effects can help to maintain cognitive
function in older adults.
We have seen that two of the most damaging effects of age to the brain are inflammation
and oxidative stress caused by free radicals.
The ingredients in Unforgettables combat against both of these adverse side-effects of aging.
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