Hi, I'm Dr Janelle Sinclair.
In today's video we're going to discuss the natural antidepressant 5-HTP, and the effective
5-htp dosage for depression.
I'm going to outline the right way to take 5-HTP covering what it is, how much to take,
when to take it, common side-effects and how to avoid them, as well as drug interactions.
If you haven't met me before, I'm Dr Janelle Sinclair, I've got a PhD in biochemistry and
I'm a natural medicine practitioner who specialises in mental health.
And on this YouTube channel, you'll find practical videos discussing effective and safe natural
therapies for depression and anxiety.
Make sure that you stick around to the end to find out about how long it normally takes
to respond to 5HTP, and what to do if you're already on an antidepressant medication.
And if you're new here, consider subscribing and hit that bell button so that you're notified
about our new weekly videos.
Let's begin, and discuss a little bit about 5HTP- what it is, and what is it used for?
5HTP stands for 5-Hydroxytryptophan
It is naturally produced by the body, and is made from the amino acid tryptophan.
5HTP converts into the happy and calming neurotransmitter serotonin.
Serotonin is then converted into melatonin, the sleep hormone
Because 5HTP can increase both serotonin and melatonin levels in the body,
that is why it is effective for both depression and insomnia.
Small studies suggest that 5HTP is as actually effective as standard antidepressant medications.
5HTP has been used clinically for over 50 years, and the conditions that it's commonly
used for include depression, anxiety, insomnia, fibromyalgia, headaches, and obesity.
This video is about using 5HTP for depression, so let's discuss the effective dose, when
to take it and how to avoid side-effects.
5HTP is a simple supplement that can be purchased from a pharmacy, a healthstore or online.
It is produced commercially by extracting it from the seeds of the african plant Griffonia
simplicifolia.
It is absorbed very well when taken orally, with 70% of the dose getting into the bloodstream.
But before I tell you how much 5HTP dose to take for depression, if you are already on an antidepressant
medication I want you to promise me that you will watch the next section on drug interactions.
Okay? Good.
The most common starting dose of 5HTP for depression is 50mg three times per day (usually
at breakfast, lunch and dinner).
If you struggle with poor sleep you may want to take the third dose before bed.
If you haven't seen an improvement in your mood after 2 weeks, on 50mgs three times per
day, increase to 100mgs three times a day.
Some studies have used up to 250mg three times per day, this is safe but it isn't a common practise.
Also keep in mind that 5HTP can help reduce anxiety at doses around 150mg, but at doses
above 225mg per day it seems to worsen anxiety symptoms.
5HTP can be taken either on an empty stomach or with meals. It really doesn't matter.
Some people think that the other amino acids in food will interfere with the uptake of
the 5HTP into the brain, however this isn't the case.
5HTP easily crosses the blood-brain barrier, as it does not require a transport molecule to do this.
One side effect of 5HTP is that if you take it with meals it helps to increase satiety,
that is- you feel fuller quicker.
So 5HTP can be helpful for weight management and appetite control.
That's a great side-effect isn't it.
5HTP does have some other side-effects, but these can be avoided or reduced if you follow some simple guidelines.
The most common side-effects include nausea, stomach upsets, headaches, insomnia and palpitations.
The severity of these side effects are usually dose dependent and are also related to how
quickly doses are increased.
So start at the lower dose of 50mgs three times a day to avoid these
And if you're someone that is very sensitive to supplementation in general or you get these
side effects straight after starting the 5HTP, then I'd recommend you just start on
50mgs once a day, and work up slowly from there.
Is this all making sense to you?
Give me a yes in the comment section below if it is.
Now let's move on to consider any potential interactions between 5HTP and medications.
The interaction we need to worry about is combining 5HTP with medications that increase
serotonin in the body.
Because both the 5HTP and the medications increase serotonin, there is a risk of
serotonin syndrome and cerebral vasoconstrictive disorders.
These medications include tramadol, a common pain killer, and antidepressant medications
including SSRIs, tricyclic and atypical antidepresants.
You may know these are citalopram, fluoxetine, paroxetine, sertraline, amitriptyline or clomipramine.
If you're unsure check with your doctor.
While some people take 5HTP while they are reducing their antidepressant medications,
I suggest that you only do this with the guidance of your health practitioner.
So if you're on an antidepressant medication already,
I don't think 5HTP is the best option for you.
There are lot of other natural supplements for depression, that can be used at the same
time as you're taking antidepressant medications.
I'll discuss that in a moment.
But first I promised you that I'd tell you how long it takes for most people to respond to 5HTP.
Well 5HTP actually works quite fast, and a large majority of people experience some improvement
in as little as 3-14 days.
If you don't feel a lift within 2 weeks, increase your 5HTP dose as I suggested earlier.
And if after 6 weeks on 5HTP you haven't experienced an improvement I would personally recommend
that you consider a different avenue.
Rather than taking lots of different natural supplements for depression on a trial and
error basis, my approach is to rule out and then treat naturally any underlying
biological causes for depression or anxiety.
For example, if we find you have a nutrient deficiency that can cause depression, we can
use a mineral or vitamin to treat it.
If you find a hormonal imbalance, herbs or natural hormones can be used.
If a blood sugar imbalance or a gut dysbiosis is found, we can use diet and supplements
to treat these factors.
I discuss these imbalances and how to treat them a lot on this YouTube channel.
If you find that 5HTP doesn't work for you, you're already on an antidepressant medication
or you want a more personalised approach, then I suggest that you learn more about the
biological causes of depression and anxiety. I've created a playlist on that topic here.
There's an overview video, and also information on vitamin D deficiency, zinc deficiency,
gut health and I'll be adding more videos to it over time.
And if you've found this video helpful, like it and share it with a friend.
Thanks for watching and I'll see you in the next video.
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