Waching daily Nov 3 2017

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For more infomation >> STEWIE2K is ON FIRE! TOP PLAYS in CS:GO! (2017) - Duration: 10:31.

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Why Is There an Opioid Crisis? - Duration: 5:21.

Last week, the opioid epidemic was declared a 'public health emergency' in the United

States — something advocates have been pushing for a while.

Because at this point, experts agree that America is in the middle of an opioid crisis.

According to the CDC, around 90 Americans die from opioid overdoses every day

That's about as many as those who die in car crashes.

There are all kinds of different factors that led to this crisis.

But the main reasons have a lot to do with what these drugs are, how they reduce pain,

and why they're so addictive.

First, some terminology.

You hear people throwing around words like opioids and opiates, not to mention heroin,

oxy, and fentanyl.

But those mean different things.

Opioids are any drug that acts on opioid receptors on your cells.

Opiates are essentially the same, but they're made from the poppy plant.

Yep, the plant that gives us lemon poppy seed muffins also makes opium and morphine.

So opiates are natural, while opioids include both natural and synthetic drugs.

For our purposes, what matters is that they all bind to opioid receptors on cells around

your body, like in your brain and spinal cord.

These receptors come in different shapes, like mu opioid receptors.

And when opioids bind to receptors, it makes it harder for neurons to send along signals

that get interpreted as pain.

This happens in the spinal cord, where peripheral nerve cells pass on incoming signals.

And it happens in the brain, where neurons in a region called the periaqueductal gray

prevent cells from releasing neurotransmitters, which are basically chemical messages.

All this means opioids are really good pain relievers.

And in the 1990s, because of a combination of factors including misrepresented research,

doctors started prescribing more painkillers like oxycodone and hydrocodone to try to treat

pain.

But opioid receptors are also in reward centers of the brain, and binding to cells there can

create euphoria, which is that 'high' feeling.

That's what makes them addictive.

Plus, your body builds tolerance to them pretty quickly, so you need more of the drug to control

the same amount of pain.

You can also become physically dependent, experiencing symptoms of withdrawal if you

stop taking the drug.

Since neurons get used to the opioids, they become more active to compensate for the drug

suppressing signals.

And if it's no longer there, the cells become way more active than normal.

So you can become agitated, anxious, or feel like puking.

Addiction, on the other hand, is a psychological condition where you seek out the drug despite

the damage it does to your life.

While physical dependence is common with addiction, a person doesn't have to be dependent to

become addicted and vice versa.

With the opioid epidemic, it's thought that many people who originally took the drugs

as prescribed started to take more.

In other words, they began abusing them.

And when pills became too expensive or difficult to get, they turned to heroin, an opioid made

from morphine, which was more readily available.

Regardless of the source, the addiction can turn deadly because of the other physiological

effects of opioids.

That's because opioid receptors aren't just in areas of the brain that control pain;

they're also in the parts that control breathing, like the brainstem.

And when they block signaling there, opioids slow down and can even stop breathing.

Doctors call this respiratory depression, and it's usually what kills people who overdose.

Fortunately, we now have some ways to counteract overdoses.

For instance, naloxone can be injected or squirted up someone's nose and, within minutes,

seemingly bring people back from the dead.

It's actually an opioid, too, since it binds to opioid receptors.

But unlike heroin or prescription painkillers, which are agonists, naloxone is an antagonist.

That means that when it binds to a receptor, it doesn't turn on any of the usual effects.

Instead, it acts as a blocker.

Naloxone works so well because it binds to opioid receptors more strongly than the overdosed

drug.

So it can flood your system and prevent the drug from binding.

Problem is, you need to treat someone with naloxone pretty fast.

It doesn't always take long after an overdose for them to stop breathing.

And that's especially true if they've taken one of the stronger synthetic opioids,

like fentanyl.

Fentanyl is a prescription drug that's around 50-100 times stronger than morphine.

Because of its structure, it can cross a protective membrane called the blood-brain barrier more

easily, which means your brain can get flooded with the stuff faster.

Lately, illicit versions of it have been added to heroin and other drugs sold on the street.

And other, fentanyl-like drugs are even more powerful, like carfentanil, which is used

to tranquilize elephants.

Not only do these drugs cause faster overdoses, but they also need more antidotes to counteract

the effects.

So even if the person is given a treatment like naloxone in time, there might not be

enough on hand to save them.

Deaths from overdoses have spiked in recent years, and as the problem has gotten worse,

experts have been trying to figure out how to deal with it.

For the most part, doctors are starting to cut back their prescriptions of opioids, which

should help reduce the number of people who go on to develop addictions.

And researchers are working on finding opioids that can knock out pain without all the dangerous

side effects.

Some groups, for example, are studying drugs that are closer to the opioid peptides our

bodies make, which may bind to receptors in more specific ways.

But in the meantime, there are already a lot of people out there with substance abuse disorders,

and helping them get into treatment is a whole other challenge.

So, there's still a lot of work to do.

Thanks for watching this episode of SciShow and thanks especially to our President of

Space, SR Foxley!

We really appreciate your support.

And we really appreciate all of you for watching too!

SciShow wouldn't exist without you, and we want to learn more about who you are and what

you'd like to learn from us.

So, we're doing a viewer survey right now that you can fill out to let us know.

If you haven't taken it yet, there's a link in the description where you can go do that.

Thanks!

For more infomation >> Why Is There an Opioid Crisis? - Duration: 5:21.

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"This Is My Brave" production tackles mental illness - Duration: 1:06.

For more infomation >> "This Is My Brave" production tackles mental illness - Duration: 1:06.

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John Kelly is not honorable Rep Gallego MSNBC - Duration: 5:22.

For more infomation >> John Kelly is not honorable Rep Gallego MSNBC - Duration: 5:22.

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Robert Irvine Show (November 03, 2017) A mother is tired of dealing with her... - Duration: 38:50.

For more infomation >> Robert Irvine Show (November 03, 2017) A mother is tired of dealing with her... - Duration: 38:50.

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Midlife Mastery for Women. What is it going to take? - Duration: 2:25.

If you're a woman, what are the biggest, challenges that you face today? My name

is Audrey Doepker, and I interviewed women ages 38 to 62 and I asked them what their

biggest challenges, fears, and frustrations are as a woman in midlife today.

Right across the board, no exceptions, they told me that ...

their health is their biggest challeng. And when they went on to list their fears

and frustrations, what they didn't realize is that all of them are tied

directly to their health. Now women in midlife searching for health and healing

is nothing new. Mass advertising, fads and gimmicks that are too good to be true

have created a world where we, as women, are always searching for the next new thing.

These things just don't last, and there's a reason for that.

How do I know this? Well I know you because I am you. I've been searching for health and

healing for the last 15 years. Healing from a disease that almost took my life

twice. Healing from a very tumultuous divorce, all that it takes to be a single

mom, heartbreak, severe loss and grief in my family, career turmoil.

Just always trying to get my life back on track. Trying to find that feeling that

all women WANT TO feel. And I need to share with you what I've discovered, as a woman

in midlife, looking for health and healing today ...

that no matter what your health goals are ...

we've been starting in the wrong place.

We're gonna simplify this. We're gonna work with the tried and true,

the time-tested strategies that can change your life just like they've changed mine.

Once you immerse yourself in what I'm about to share with you

everything else can more easily fall into place. Instead of this long-standing

fear of our future let's create a FAITH in our future. I'm not fooling around here,

this time we have to do this! Join me! It's just damn time.

I'm going to create a movement of women who are MORE THAN ready to be healthy,

to find health, and to live a wonderful life. Join me!

For more infomation >> Midlife Mastery for Women. What is it going to take? - Duration: 2:25.

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Financing v Paying Cash || Why Cash is King - Duration: 8:27.

Alright we got a lady that buys a TV so we have a lady I don't know her name but

we'll call her lady and we have a TV

that's 1250 $1,250 it must be a really really big TV and we also have a guy

that buys the exact same TV so she paid TV I'm sorry she paid TV she bought the

TV so the lady let's write down the TV up there so he got a lady that paid cash

she paid cash for that TV she walked in with a bunch of $20 bills and says huh

what can you get me and I'm guessing they're not telling the holster but I'm

assuming maybe this TV was $1,400 but she's like well I could give you 14 or

$1,250 right now like all right we'll take the 1250 because then they have

1250 in hand they don't have to work through a credit-card company they'd

have to wait for money to come every month so they say all right we'll give

you a discount and usually if you're gonna pay something with cash you'll get

a discount for it because again cash is incredible people are like oh I want

that money I don't want to wait for it and now you got a man who buys the exact

same TV but he finances it so we got a lady right there we got man I'll put man

right here he finances the TV finance is such a fancy sounding word for meaning

I'm gonna not pay it all at one time so basically he's constantly losing out on

his finances every month because he's paying for it but finance it just sounds

like so professional doesn't it I know let's see so how does he pay for this so

at the store how much does he pay

300 $12.50 up front we call that a down payment so it's like I have I don't have

that much money but I do have three hundred and twelve dollars and fifty

cents I'll give you that right now and then how else does he pay for it or

what agreement does he come to so he'll pay will pay eighty five dollars and

fifty cents per month work for twelve months so the question is this lady has

it one and done she's paid this guy for the next year he's gonna be paying for

his TV and probably by the next year the technology for TVs will go down but you

know that's what people do so the question is how much is this guy paying

in total how would I figure this guy out

no eighty five point fifty times twelve I'm just gonna write at times 0.5 times

twelve now I'm gonna use my fourth grade math my distributive property so that's

a ten and a two right so what's eighty five point five times ten move the

decimal so that's eight hundred and fifty five dollars plus what's eighty

five point five times two so when you add those together one two and six one

zero two six there you go I forgot the caring adding that zero so in that year

he paid 1026 but don't forget he also paid that upfront so the total MOT he

paid is ten twenty six plus three twelve fifty which is one three three eight

fifty

because people want to look cool that's a very good question people want to

spend money so they could say oh I'm rich when really they're well and

they're making themselves poor by spending more money they want to look

rich but they want to become poor looking rich so how much more did this

guy spend so the man and take away the lady that's what he's spent 8 - 0 is 8

what's 13 - 5 good 8 so this guy was like I want that TV I'm willing to spend

eighty eight dollars and fifty cents more so I can have that TV now so take

away the lady and you end up spending more money so I guess it says in

Proverbs a Good Wife it's a good thing to find then I suppose that way you save

eighty eight dollars and fifty cents that way so that's basically what this

lessons about you're gonna see paying for something up front and then the

financing you so don't forget that you have to include what you paid for up

front plus however long you paid for that kind of thing now this is very

basic this is like an agreement that would come to other problems would deal

with like finding the percentage of it like if you look at car deals and say oh

you can pay up front and pay five percent so in that case you have to

actually figure out the five percent but right now the basic idea right here this

is the agreement this guy came to figure out how much more you're doing it that

way than it is for just paying up front and again I want you to realize if

you're paying for something upfront with cash I guarantee that those guys will

give you a deal and if they don't guess what you could do take your business

elsewhere but then they'll be like oh my goodness

but then you got it really be willing to do that because if you make it look like

you want that thing those salesmen will know that they're trained to know they

can read your body language and say oh this guy really wants it so I'm just

gonna push it as much as I can oh let me go talk to my boss over here

they go to talk to their boss they're not talking to their boss they're just

using somebody else to make it sound like oh this guy's so mean I'm trying to

help you out but I can't because my boss is being mean and then they're gonna be

like they'll assume that you'll be like well you know what he was trying

oh well I'll despite no that's just a tactic in fact you should do something

like that you should have like well you can I could say something like I want to

buy something I'll say ooh I want to get that well it'll cost this much I'll say

oh you know what my wife would not want me to spend that much money on this kind

of thing I better not do that so you can do the exact same thing they're doing

and then they'll be like well let me cut you a deal Mike all right that sounds

good yes yeah yeah see that there you go yes

for a credit card I'm in eighth grade I don't have a credit card okay but you

notice them but you learned something from that that guy is willing to go down

in price because you're willing to walk away you didn't make it look like oh I

really want that let's see how far I'll go it's like it's more like I don't have

the money I'm just gonna leave I'm gonna take my business elsewhere here look all

lower here I'll over here because he wanted your cash so any thoughts on this

any other questions or thoughts on that all right so learn how to walk away and

then you don't have to worry about spending eighty eight dollars and 50

cents a man that's a lot of money man oh man call of duty