Waching daily Dec 11 2017

SORRY FOR THE WRONG TITLE GUYS, ITS AAMRAPALI DUBEY FOR YOU

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IS THAT ENOUGH>

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SO NICE NA

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For more infomation >> AAMRAPALI DUBEY FAN STORY - 1 (SORRY FOR NAGMA TITLE) - Duration: 4:34.

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President. Donald Trump Records Robocall For Roy Moore | NBC Nightly News - Duration: 2:15.

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Live With Lee & Hayley: 18 Gifts For Christmas: Moshi iPhone Cases - Duration: 1:16.

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Live With Lee & Hayley: 18 Gifts For Christmas: Portovino Purse - Duration: 3:33.

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Sea Trials for US Navy's New Stealth Destroyer Cut Short Due to Equipment Failure - Duration: 0:58.

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Discovering Bacterial Genes Required for Wound Infection by Kelly Michie - Duration: 3:25.

- Next up will be Kelly Michie from biology,

speaking on Gotta Screen 'em All,

Discovering Bacterial Genes Required for Wound Infection.

- Can you imagine having an infected painful open wound

that will just not go away?

In fact, every year 6.5 million Americans

will suffer from a chronic wound infection.

By definition, chronic wound infections

take three months or longer to heal.

One of the most common causes is a bacterium

called Pseudomonas aeruginosa.

Pseudomonas is associated with increased wound severity,

prolonged healing times, and higher mortality rates.

In order to develop more effective treatments

for the chronic wound infections,

it is vital to better understand

how Pseudomonas causes these infections

on the genetic level.

How do we do this?

With genetic mutants.

A mutant simply has a non-functional version of a gene,

as represented by these different colors.

Traditionally, researchers infect mice

with individual Pseudomonas mutants one at a time

and assess how each mutation

affects Pseudomonas' ability to cause disease.

However, these methods are very laborious,

require large numbers of mice,

and only a limited number of genes can be tested.

For my research, I am instead using a new,

highly efficient method called Tn-Seq.

With Tn-Seq, I infect mice

with a pool of hundreds of thousands

of Pseudomonas mutants simultaneously.

This allows me to test nearly all of Pseudomonas' genes

and identify the ones that are important

for chronic wound infection.

Furthermore, while chronic wounds are relatively common,

they are rare in normally healthy people.

This is because both patient genetics

and predisposing conditions like diabetes

influence a person's risk.

However, very little is actually understood

about these interactions because with traditional methods,

often only one genetic background and process is used.

The novelty of my research is

that I am performing Tn-Seq with a panel

of 16 different types of mice,

each with a different genetic mutation

that causes a clinically relevant immune

or metabolic disease that is found in humans.

This includes mice with diabetes, high cholesterol,

and different immune system deficiencies.

The outcome of my research will be a list of the genes

that are important for Pseudomonas

to cause chronic wound infections in mice

with a variety of predisposing conditions.

This information will be useful,

both to the development of new antibiotics

and for advancing personalized medicine

for patients with predisposing conditions.

Ultimately, I aim to lessen the disease burden

caused by chronic wound infections, thank you.

(audience applauds)

For more infomation >> Discovering Bacterial Genes Required for Wound Infection by Kelly Michie - Duration: 3:25.

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Force1 UDI U818A Camera Drone for Kids - Duration: 2:39.

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