hello everyone and welcome to the kids
first webinar for the x1 pre-application
discussion
my name is wretched boy and I'll be
doing introductory part of the webinar
um I'd like you to go over a few
instructions so that you understand how
we're going to operate the webinar on
the program is being hosted by the
Gabriella Miller kids first pediatric
research program and several of the
people involved in the program here at
NIH will be talking with you today right
now all the participants are music upon
entry for the webinar and we ask that
you please remain seated until the
question or discussion period at the end
of the presentation and that's how you
can unmute yourself by selecting start
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on the webinar you can ask technical
questions at any time using the chat
service through the webinar to the host
if you are having technical difficulties
please feel free to use this means of
communication please save any questions
related to the program or funding
opportunity announcement for the
question period at the end and it's my
chance you have additional questions
after the webinar is over please feel
free to email them six his first Cody's
at iah not go and just a reminder we are
recording the webinar and the recording
will be posted to the kids first website
in case you want to review any aspect of
it or you have colleagues that were
unavailable this time to listen to live
so this is the pre-application webinar
for the discovery of the genetic basis
of childhood cancers and structural
birth defects the Gabriella Miller his
first TD after research programs
excellent one initiative and before we
get into the details of the funding
opportunity announcement but I want to
provide a little bit of background
information and introduce to you the
people that comprise the church
leadership group here at NIH we have a
number of programs involved isn't common
fund projects as you know it was
initiated in 2014 2015 with the overall
goal of establishing its first a
resource for the pediatric research
community we find we're very excited by
this opportunity both for Ali a chance
for the PDF research community programs
focusing on structural birth defects in
pediatric cancers and this is a comment
on program leadership responsibilities
are being shared across for NIH
Institute's Wallace college but the
people listed on this slide are the
folks that are involved in coordinating
the program as i mentioned i'm erection
boy i'm a program officer and I chg
Jonathan called mentions from NHLBI and
he and I are the points of contact for
special birthday sex questions of
themselves solve is an NHGRI and along
with James cool
nichd there the point of contact for
people in questions
James the project officer for the first
statement punters Nelson S&J goodra all
our program officers of the National
Cancer Institute and there are the point
of contact for ideas
PS answer questions
and Martin lurkey is the is involved
with our data resource project which
essentially funds this year will be the
process by which coordinating our
efforts from the common funds we have
very serious who is our program officer
and my instructor who is the operations
and budget person we also have a person
who handles policy planning evaluation
indication for us it was Josie honest we
recently lost them to another position
here at NIH more the process of getting
someone new and you all are probably
familiar with Valerie cotton who is our
administrative points1 coordinated
application and webinar today I just
want to take a moment to point out that
there's more than usual interest in this
program from both Congress and the other
50 communities partly because the way
the program change to be and today we
have stepped ishe of the Common Fund on
the line with us shoot the team leader
for the policy planning evaluation and
communication boxes and she's filling in
in the role of communications person
today during the webinar but you have
any questions on this aspect of the
program should be able to answer them
during our discussion period so the
people highlighted involved on this
slide myself and John Colin and Valerie
hot and will be the people talking with
you today during the course of the
webinar can XYZ I just want to go
through a bit of background as to how we
got where we are today so the program
was initiated and respond to the 2014
Gabriella Miller its first research act
which was signed into law and a third
2014 this law actually did three things
it ends attacks their contribution to
the presidential nominating conventions
and look at the small graphic at the
bottom of the slide visit the snap of
the other portion of your IRS 1040 and
the area highlighted in red was actually
a little checkbox that existed on
1040 back and your prior to 2014 and
2014 which allows taxpayers to
contribute tree dollars towards the
presidential nominating conventions fun
turned out a lot of money with cities
and the funds wasn't being best but the
times long past what it did was it
authorize the transfer of a hundred
twenty-six million dollars which were
sitting in the fun into a new pediatric
research initiative but it also
authorized congress to appropriate 12.6
million dollars a year for each of 10
years directly to the nih common fund
for a new pediatric research program and
the first appropriation was accomplished
in fiscal year 2015 think from our
perspective in bunny the program the
most important word on the slide is it
authorized the appropriation on an
annual basis so very important to
remember that this program there is a
mandate for 10 years of funding were
dependent upon congressional
appropriation annual basis to get the
funds for the program which artists back
to my earlier statement that there's a
lot of interest on the part of advocacy
group to see the captain's on an annual
basis
ok so if we look more closely at his
first working group as i mentioned as a
transit is effort supported by nih
common fund the Institute's that Sheriff
his first working group are the Child
Health Institute hard ones laws cancer
institute and the genome Institute it's
very important that you understand there
are a number of other is that you
working on this program and they're
listed here on the slide so just briefly
reiterated fidelis to choose the drug
Institute alcohol diabetes and kidney
Environmental Health Sciences the eye
and tissues are prized the
musculoskeletal diseases infectious
disease and the office research
instruction program
and we also have an ex-officio member
from the CDC's birth defects division
sitting on the working group so we've
got a lot of people involved in this
program and want you to be aware of this
because if you're interested in applying
to the exelon program it may be that you
your mission align more with one of
these other institutes and you should
feel free to contact program officers
you know what these Institute's that you
have questions about how relevant what
you want to do is to their mission for a
complete list of our working remembers
you can go to the kids first Common Fund
West fight and look at working group
members of the link there now I'm going
to turn the webinar over to John call
then who's going to review the program
goals
alright thank you so the overall goal of
his first program is to develop a data
resource which we are calling the
Gabriella Miller kids first p educated
resource where pediatric research
community can access well-curated
clinical genetic sequence data that will
allow them to identify genetic pathways
that underlies childhood cancer and
structural birth defects a greater
understanding of the genetic
underpinnings of these pediatric
condition is critical for developing and
improving preventive measures for
diagnostics is the character
intervention there are three main
edition is supported his first program
they include cohort identification DNA
sequencing the cancerous data resource
and data analyses
we'll talk about the first one goes late
today although i'll i'll briefly
mentioned what that the other two will
be doing swell cover identification the
DNA sequencing is accomplished during
the excellent program which will be the
topic of discussion to a rule is to
identify cohorts that children with
either childhood cancer or structural
birth defects more bone and their
families for whole-genome sequencing
concerns before the whole genome
sequence take of these cohorts to
elucidate the genetic contribution to
childhood cancers and a genetic etiology
of special birth defects the pictures
pediatric data resource will be awarded
an established later this year
the goal of this reasonable to develop a
web-based portal that will aid
researchers in identifying cohorts that
are available and have a sequence data
and that will also facilitate out cross
cohort analysis and it finally street
analyses conditions which is further
down the rows will be set up after the
resources of the naughty and will
further support analysis of kids
regenerated as well as knowledge it is
generated data to uncover new insight
into the biology of childhood cancer she
shows us now to talk about the extra
watches need a third cycle of our extra
1i it's currently called discovery of
the genetic basis to challenge cancers
and instructional 30 secs the first one
was released in 2015 and
jun 2015 x12 childhood cancer cohorts
five structural birth defects covert
sequence in 2016 three childhood
Cantrell chords and five structural
represent cool ones you want and then
the current exit one is par-70 dash 63
we hope you plan to continue sequencing
for several more years provided the
funds are appropriated as right
discussed and that cohorts are available
funding announcement has slightly
evolved over the three years of the
program in particular lesson emphasis
being placed on the minimum number of
samples also less than s is being placed
on trio design as long as there is a
valid analysis plan that accompanies the
overspeed proposed just a word about the
actual one back isn't the extra one is
not a typical award mechanism or typical
grant mechanism there is no award that's
given to the recipients and in fact
there is no notice of award recipients
are selected for the opportunity to have
their co-worker sequence again no funds
are provided more analysis but there is
an accompanied ro3 which is PR 16
dentistry 48 which originates from nichd
but has the number of partners that
supports analysis of data that is
generated by the excellent project also
these awards are not listed the is
reporter but abstracts from our prior
awardees are listed all the kids first
website the
web addresses on your street no
alternative about Valerie so i'm not
really tired and at laura is my a
program analyst 4-h program and a large
part of my job is to be able to speak
with the intent of fat as well as the
sln investigators will be selected
through PR 70 degrees i'm going to go
over some details that will hopefully
help you with your application to this
half fish and some of the information
about to cover is already addressed an
RFA Hughes if you are considering
applying for this at all i highly
encourage you to look at her if you
think you can find on our Facebook first
combines website at this link here we
can offer constantly updating faq will
update them after today of the questions
that we get the discussion that we have
and we see them on an ongoing basis as
we get everything for you see us
becoming centers that are providing the
UC printing services so that i described
in the so one away
they were selected for cooperative
agreements and we will be working with
such as for three years starting in
fiscal year 16 those cohorts have
already been selected and the samples
are being shipped and they're answering
the secret life around now I'm gonna be
working with them
physical you're 18 the first answer is
because been outside Institute provide
technology but I thought we'd be in
partnership with speak to children's
research hospital but by my exact the
other sensor is the grossest issue of
harvard and MIT like myspace Behavior
all photos of the sensors have the
capacity to sequence both cancer process
and birth defects projects
however our plan is to assign all kinds
of projects to the sequencing center
husband else's shoes to take advantage
of the analytical expertise for
identifying somatic variants that was
offered by the center and but depending
on the application as we can
exposes better proposed by with a
coworker left behind a process may not
work out exactly this way but this is
our general framework to see screen
centers are tests with 40 the sequencing
as well the variant calling I've already
ate things of DNA and RNA so that means
that will generate the variant calling
vials as well as bands and in some cases
that cute smile because cohorts will
receive holiness sequence paying an
average of thirty x coverage of cancer
called board will also receive 3x
coverage for whole-genome sequencing for
journalists sample but one change in
this my way that we are really not
introducing the submission of nucleic
acids from tumor samples I to go to the
husband elbows Thank You Spencer was it
was generate hold my own secret thing as
well as all that something RNA
sequencing because this is an
information thanks for their analytical
pipeline you may propose other methods
or technological approaches pretty one
thing in your applications for example
this past I stole someone's for proposed
higher coverage than 30s in the end
after working with us and our sequencing
centers they determined that 30s was the
most reasonable they would have free
sample size they wanted higher coverage
and they decided that the higher
simplifying the more valuable so on this
is an example of how you can propose
other things but the final product
design will be decided among discussions
with excellent investigators sequencing
center shaft and a nice program staff
another possibility that you might be
interested in proposing is a lynx long
new sequencing this is actually a
technological approach that was a pro
proposed by mostly sequencing centers
but since this is a new technology we've
actually asked them to work together to
run a small pilot study and this is so
that we can evaluate and better
understand the added value of utility of
this approach for these types of comfort
for birth defects and pediatric cancer
those they're doing this using 10x
platform so based on the results of a
pilot studies this is something that may
become more available for future
opportunities including this one so this
interests you at all
I encourage you to describe this in your
application and you invited application
for why you think it might be useful
your code for I just want to take a
moment and talk about where data lives
and how it's accessible so all this
hurts that you will have to be
registered in DB gap if you're not
familiar with unique a pin and I a
system for facilitating control access
of genetic data to other researchers so
you would be the time to research
research area generating the data but a
goal is to make this accessible to other
researchers as well and the end pts was
sort of a keeper out that process so I
projects well beyond the certain TV gap
sumx and i will also be submitted a gap
of sequence Dana will be submitted to
ncbi sequence read archive actually the
sequencing center will be responsible
for them but i just wanted to make sure
you guys need to wear daily living
intertitles of cancer process they also
have to be resurrecting PDF but all data
my assessment make that and sequence
data will be submitted to NCIS genomic
data Commons this is a database that was
launched within the last year it's still
a little bit new show NCIS that working
with us and our investigators and see
sequencing centers to make sure that we
get the necessary information from each
project properly submitted so now i'm
going to address a few of our
expectations are requirements in terms
of what his first program goals are so
from the beginning we've been very
focused on whole genome sequencing to
discover Connecticut
is contributing to these pts condition
but we had the opportunity for full deck
so it's just transfer zone season of
humor as well based on the proposal and
the value of this argued by uzma thank
you
so given these are just because they
develop them be performed our efforts
expectation is that the DNA and in the
case of tumors are named as well
exceptions that you plan to submit are
sufficient quality and concentration of
these technologies will talk a little
bit later about how we ask you that
information is the application another
goal of the program is justin silicate
cross-court analyses base and these be
done based on common development one
very large task of our upcoming his
first date of resource will be to
harmonize phenotype across all of our
process so to this end we really need
some basic element but the better the
more details happy that you have the
better
um for birth defects projects we don't
have established set of standards for
phenotypes data but since the candidate
will be going into NCIC economic data
comments they have already clearly
established the elements that they
expect for my assessment and clinical
and you know Vegas so you can find this
swing here and also in our FAQ to look
at that you use data dictionary another
goal of ours is programmed out and so we
meet to run the diversity of both PSR
cancer and special birth defects data
says that will initially be part of our
kids first data resource this means that
if we get a lot of applications of me
hopes that we knew and we are faced with
the choice of cute very similar
applications but one of the proposals of
sequencing of the condition that we
haven't covered before we are more
likely to select that cord
this doesn't mean we can serve you broke
lying if you have a cohort of similar to
what we've got the board that we want to
be a parent
office and we in previous life if you
link to where you can find the list of
quickly statements before and we
encourage you to look at that huge goal
ours is data sharing so to make the
animated by our program as acceptable to
be this community as possible so in line
with NIH's no mysterious errand policy
cohort participants must have your
physics consent to allow the sharing of
individual level sequence and the
associated seen effective at through
high approved repository the classic
example EE gap another priority of ours
is to make sure this data to go to as
many as are constantly service possible
so we are most interested in doing that
is impressive to share as broadly as
possible though something that submitted
for general issues something that is
constructive for health medical or
biological research is preferred over
busy specific data use restrictions and
it's just because we want to promote
collaboration long investigators as much
as possible and then just because a
little bit more complicated with data
sets are restricted success researchers
again it doesn't mean we discourage you
from applying that you have is the
specific restrictions of but we do ask
that you previously that your
application and some of you like us is
recruiting you court or even be
confessing for every anyway as me and I
have guidelines two guys using who have
made with that allows for grass sharing
sample size and family structure as John
mentioned in previous years we really
focus on his trio base designs of what
we realized that there are other family
structures and designs out there that
can lead to discovery but this needs to
be very clearly communicated in your
application of obviously the larger the
sample size the better
um in some cases we have birth defects
of in Hawaii we talk about the birth
defects minimum 100 trios
but if you less than that I'm we would
like to see you so I clear scientific
justification for how you will be able
to identify the Americans if your sample
size not that large very strongly
encourage you to consider collaborating
with other investigators cool samples
together for larger sample size and of
course in the case that you don't have
trios use this week you on show us an
argument for how us that you have enough
program and toss that you will see Chris
enough effective and/or unaffected
family members to be in any discovery
and this type and very closely with
analysis Lance the goal asking for
analysis plans in these applications if
you have investigators seven days that
the proposed project has an adequate
research design for genetic discovery
and that usps one investigators are in
addition to responding analyses so one
of modification of this iteration of the
F away is that we do communicate that we
recognize the analytical power of each
dataset will increase once incorporated
with all the other datasets that are
part of his first no class it is
important that you demonstrate the data
will be usable on its own
if you feel that your team does not have
the analytical and little call our
statistical expertise to perform these
now is we highly encourage you to
partner with another group who may be
able to work with you on an analysis
plan so now i'm going to move on to
adjust a part of b funding announcement
called other attachments entire years
we've always discussed the institutional
education of indiscretion but from this
year we greatly expanded this part of
the application of to ask for sample
information description of the penis
penis
any description of the family structures
and even after this here that we want to
enable you to submit supplemental
additional material all the explaining
and response to make me a sport here
without really cutting into your limited
user strategy so we have also created a
optional downloadable form that is
available on earth a fuse and that is a
template where you can give us the
information that was asking or this is
awesome
you may choose to respond this
information that we need and in another
format whatever way is best for you by
the Board says as a place where both
applications and reviewers can look at
work with the uniform document
information can be organized and I'm
going in the next slide right over
easily use one by one so the first
attachment would be the official
certification or criminal certifications
or sample consent form institutional
certifications are documents that sure
is that these innovative new BFF pieces
and i use genomic data sharing policy of
many team cannot usually get a full
official official certification from
their ir e until after the board or the
state after you left yet so one program
so you need to remind the original
certification or the simple consent form
instead we use after the presentation
please use the current and I Swiss can
be found at this link that's where you
can find both institutional education
and the cell certain cases that's what
no matter what you submit it needs to be
clear need to cover all the sites that
contribute simple to your project nice
to specify whether being a competitive
presented the energy gap or other and i
use repository and organizations need to
be very clear bass playing
this snapshot below is a msg from the
institutional certification but you can
see how automatically you will have to
organize and label that spreads arms but
if you're not submitting a full official
certification with your application you
need to describe them somewhere else the
application and i just want to mention
that no matter what you submit with your
application if your cousin is selected
you will have to provide the school and
Cisco certification using this template
shortly after we notify you know your
project has been selected and this is
the first step of that he got
registrations I talked about we're not
going to get into the details here just
know that i SAT here to help you with
this but this would be the first step on
the other questions we asked for our
sample information so we really need to
understand the total number of samples
that you are proposing for sequencing
very clearly again you can modify this
table you can submit this the
information in the s4 whatever way works
for you but this is one way you can
organize these details though this table
of the rows are organized by sample type
or or DNA or RNA source this hot part of
this table would be for both birth
defects cohorts and cancer cohorts and
the bottom part is for tumor sample for
testing project we just need you to
describe the number of samples from heat
exhaustion message that was used the
concentration some never got quality and
tell us which metra could use a method
of quantification and then we need to
know how how many samples will be ready
to ship by August 2017 and if you slide
I'll talk more about the timeline of
this program but we anticipate that we
will be notifying crew being selected
under this so17 team iterations in the
life so we are hoping that we will be
getting bigger than our samples of
pipeline by august but we realized that
types there are some lingering
extractions pencil penis off and
sometimes there are some shipping little
script coordinate so we asked for how
many samples are ready now and have
examples already six months from now
just to get a sense of what is ready to
go again you can modify this slightly if
you know that you'll have everything
ready by November of 2017 that you can
change the January 218 number 170 and
tell us when all your will be submitted
by we also ask you to describe what you
no text information and demographic
information you collected from these
participants have minimum we expect a
good diagnosis maybe maybe you have some
other Asian formation sex race/ethnicity
and then just tell us what else you
collected describe you
primary uh clinical description and I
purchase a kind heart tumor spice up and
tell us what other phenotype information
whether it's clinical or otherwise that
you've collected over also interested in
knowing what family medical history you
have this is a very general table again
we just need to who you give us a sense
of what being a kata you have available
again for cancer code words this is a
little bit more clearly laid out of the
standards provided funds you see we
highly encourage you to look at those
and again for those cohorts that are not
feel designs we ask that you describe
what the family structure bar you might
have a program parents siblings of that
you might have multiple family might
have something with his family's we
don't ask me to submit enough
information to make it clear out any
samples for family you're planning on
sequence and whether they're a bit and
then he doesn't like to see simplest to
submit a pedigree information but again
tell us who you're proposing for
sequencing if you don't have a degree
information we ask that you find another
way
makes you really make it clear what
you're proposing is a handful of people
that makes us to work from with one
group they have a trios although they
also have situations where a program and
another person three family member was
infected with some defective family
members so because needed to be clear
how many of these family-type if you
have many different family types of and
how many samples from unaffected and
family number of your proposal when a
couple other things that didn't quite
fit into other slice
we just want to emphasize that another
change to lose this iteration of this
program is that we are cruising the
submission of application up guess who
has already sequence a case or programs
through other funding but have fun
sequencing play NASA's problem of
parents four parents and siblings for
tumor if you do this you ask that you
pretty quickly just ride the sequencing
technology that uses into the program
and I was but we are certainly open
because Google we also an SS opportunity
is open soon is real research program
I'm and that includes collaborators of
that is real research program is because
it doesn't come with formal fund is that
opportunity for pain so for the cycles
in 2017 cycle of you made for me how
about a lot of things that we prefer a
fact but really no matter what we heard
any investigators that have a co-worker
that meets the minimum requirements to
consider flying as you so we're working
with our current because others until
2018 on but we also have plans to
continue sequence being in later years
so we encourage you to start collecting
samples of your requirements now but
stay and just with us about this again
what will continue continue to
sequencing as long as funds are
appropriated and so forth are now also
be you
stay aware of what cohorts are out there
this is the timeline for this cycle it
is on an earlier time lines in our
previous two years but we wanted to make
sure but he was clear on this
this funny as that was published in
December today's category 5 30 this is
the weapon are the letters of intent is
to separate them as you know these are
not required but they do help us prepare
for their review of their helpful
mark 7 is the application deadline we
anticipate that some review will take
place sometime in April but we're not
going to be between unions alive we will
work with our working group to make a
selection there are no funds associated
with this program it doesn't go to an
institution helpful to work with our
working group and then we get a
recommendation approved by the Institute
directors at Coachella or a group to
make our dividend and then we plan to
know either as of yet sighs line and we
hope to get these comforts multiplying
by august so now I'm logins the floor up
for questions
I just want to reiterate that you can
continue to reach out to us this is the
analogous memberships for which we are
monitoring you also have the hot
information for program officer Barry
who are leaders of this program in the
study and ask myself my email addresses
on this life so we'll be publishing the
TV
PS of this side effects of all
publishing the webinar recording of the
webinar and just a reminder will take
the questions now we like you have some
vocally and so you'll have to unmute
yourself if you can call them through
telephone you can select start six on
your phone to unmute yourself and if you
call them through your computer you'll
have to go to the audio connection and
select the likes of all who won't need
yourself
sounds like something yummy to
themselves and her friends
so we're ready to receive your questions
hey thanks for the presentation my name
is Craig 1 i'm calling from the
university of new mexico i had a
question regarding existing coverage
have been already uploaded to DB gap but
with a net level genotyping data what a
doesn't make it simpler to have that
already done ahead of time if we want to
get a whole genome sequencing for this
data set go ahead
not sure I fully understand the
questions you don't get a full so I've
already done uh sniff genotyping and had
already uploaded cohort data to DB gap
however we would like to get whole exome
or whole genome sequencing for this
existing cohort on that and this is data
or this is DNA out of the DNA repository
so regarding the certificates and all
the paperwork and registering for the
you know DB gap and and and the kind of
administrative requests that were
presented earlier in the presentation at
zacks exact stuff gets grandfathered in
or do you have to go ahead and you know
we do a lot of the paperwork you
probably have to work with the folks who
helped you
registers as the original trial but
probably you can piggyback this data
onto that trial we've done that it
other other scenarios that are somewhat
similar where a cohort has already
undergone friend is X equal to and then
underway whole genome was a part of this
so so that data was sort of attached to
the original code word data and
obviously that will likely simplify the
registration process that you've already
done terminated and downloaded to take
it as well thank you very much
other questions
tight
Alex writing from Pittsburgh and the
question regarding the phenotypes does
it have to be one particular phenotype
or 10 and actually the collection
includes several phenotypes
right so yet the the short answer is yes
it can
are you talking about birth defects of
war camp every four right back on it it
certainly can be a part of the idea here
was that from a genetic standpoint you
take to find a fair bit of overlap
between genetics of different types of
birth defects obviously i think an
application would be stronger from
analysis standpoint if you could make an
argument about how these different
phenotypes might be analyzed together
but but certainly that possible
and what about prenatal sample and that
would be DNA obtained from what source
ubi it will be a million pieces and when
you have ultrasound data to support the
fact that the fetus has a deep at birth
because yeah the point is that it would
be the phenotyping would be down like
prenatal ultrasound that he would be a
very unique phenotyping data sets
it's not precluded from being such as we
haven't had anything I guess we had
really consider the possibility of
something prenatal oh yeah I they're
happy scientific justification for why
we would devote resources to a prenatal
cohort as opposed to pediatric cohort it
i can imagine reviewers might wondering
about the sort of validity / accuracy of
prenatal diagnosis of which obviously
could potentially be bolstered by
postnatal confirmation of the diagnosis
but you know I think you have to make a
strong argument for why be done this way
as opposed to our exit waiting
thank you
Daniella Silva Washington I was just
wondering you know you're really quiet
my I wonder if you're not coming here my
friend boner you find another way to
make your foot ladder her outright that
better
ok so i was i I was wondering if there's
an emo concentration for DNA the new
position yet you go through a huge we
have some information about what are you
can be under the best if you want more
details feel free to contact me Valerie
or distress that loss and we talked
about that
so there is some information on our
issues thank you and my other question
was about the results so when do you
expect we would get the results back so
and and are they going to be VCF files
or are you going to send us the damn
styles
yeah so like a few people generate BCS
and band and those will be somehow
transferred back to the investigator and
the investigator will have six months to
work with their own data before it gets
released to the public through DB gap so
yes we have ways to get the vaccine
investigators a timeline for data
generation
well depend on a number of factors i
have 15 days I mind but for example of
colors that are going into the pipeline
now are expected to finish the pipeline
between four and seven minutes four and
seven months
ok and so it is expected that we have
capacities to receive vampires we do I
just want to make sure if i have to
state that on the application that
emergency or not we weren't sure you can
handle a couple words in there so have
you spoken sure so we want to know if we
have to put in the application that we
have space to receive them files for
example here we weren't sure if we're
going to receive those fires are going
to access them promote yes you you will
need to talk about your capacity of your
institution to store those vampire
okay great thanks
yeah so that's a good point of one thing
as well as but once you are electric
service program and assigned to a
requesting better
there's a lot of room to collaborate
with the sequencing center on analyses
again your application you're going to
have to tell us what what your resources
you have but just know that I'm you know
this is a partnership and collaboration
and they're really great resources and
state-of-the-art sequencing centers that
were working with you know from
everything to analysis is mostly best
but so I'm you know we're really excited
about working with us and help that
makes you and and the road so you can
keep that in mind but don't forget to
have analysis plan
well it doesn't not like we have any
other questions
I'm so I think we're going to go ahead
and wrap this up but please continue to
ask questions of us three rules all of
our lives and resources and email
addresses again this webinar will be
posted on our website and as the slides
will be posted for the links and
information as well so i'm going to be
myself now and the housetop the webinar
thank you thank you
For more infomation >> Prime Minister's Questions: 1 February 2017 - Duration: 39:19. 
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